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In vitro activity of hypnophilin from Lentinus strigosus: a potential prototype for Chagas disease and leishmaniasis chemotherapy BJMBR
Souza-Fagundes,E.M.; Cota,B.B.; Rosa,L.H.; Romanha,A.J.; Corrêa-Oliveira,R.; Rosa,C.A.; Zani,C.L.; Teixeira-Carvalho,A.; Martins-Filho,O.A..
Hypnophilin and panepoxydone, terpenoids isolated from Lentinus strigosus, have significant inhibitory activity onTrypanosoma cruzi trypanothione reductase (TR). Although they have similar TR inhibitory activity at 10 μg/mL (40.3 μM and 47.6 μM for hypnophilin and panepoxydone, respectively; ~100%), hypnophilin has a slightly greater inhibitory activity (~71%) on T. cruzi amastigote (AMA) growth in vitro as well as on in vitro phytohemagglutinin (PHA)-induced peripheral blood mononuclear (PBMC) proliferation (~70%) compared to panepoxydone (69% AMA inhibition and 91% PBMC inhibition). Hypnophilin and panepoxydone at 1.25 μg/mL had 67% inhibitory activity onLeishmania (Leishmania) amazonensis amastigote-like (AMA-like) growth in vitro. The panepoxydone...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Leishmaniasis; Chemotherapy; Immunomodulation; Hypnophilin; Lentinus strigosus.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100007
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Sawdust and fruit residues of Central Amazonian for Panus strigellus spawn’s production PFB - Pesquisa Florestal Brasileira
Vargas-Isla, Ruby; Hanada, Rogério Eiji; Ishikawa, Noemia Kazue.
The objective of this work was to perform a screening of residues of forest species of the Central Amazon to prepare spawn of the edible mushroom Panus strigellus. Sawdust substrates from 11 forest species were tested. Then supplementation with beer yeast, cereal bran and regional fruit residues in sawdust:supplementation relation (5:1 and 10:1) were evaluated. Mycelial growth of P. strigellus occurred in all the substrates composed of the Amazonian forests species, suggesting that all have potential for use in spawn formulation and/or cultivation of this edible mushroom. Among these species the substrate formulated with Simarouba amara sawdust promoted higher mycelial growth (P<0.05). The formulation of S. amara supplemented with Astrocaryum aculeatum...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Basidiomycetes; Edible mushroom; Lentinus strigellus; Lentinus strigosus; Simarouba amara; Astrocaryum aculeatum Basidiomicetos; Cogumelo comestível; Lentinus strigellus; Lentinus strigosus; Simarouba amara; Astrocaryum aculeatum.
Ano: 2012 URL: http://pfb.cnpf.embrapa.br/pfb/index.php/pfb/article/view/314
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